Background Despite the increasing rates of patients diagnosed with major depressive disorder (MDD) in Jordan, there is little knowledge available about the factors associated with the quality of life (QOL) among this population in particular. Aims This study aims to assess the level of QOL among Jordanian patients with MDD and to examine the possible correlates of QOL in this population. Methods A descriptive correlational design was used. A convenience sample of 161 Jordanian outpatients suffering from MDD completed the study. Participants completed the demographic questionnaire, measures of depression severity, stigma toward mental illness, and QOL. Results Participants reported poor QOL in all domains. Age, income, stigma toward mental illness, and severity of depressive symptoms were significantly correlated with QOL among the study sample. Multiple hierarchical regression analysis revealed that the severity of depressive symptoms is the strongest correlate of QOL, which accounted for 24% additional variance above and beyond the 18% variance accounted for by all other variables. Conclusions This is the first study to assess QOL in an Arab population with MDD. Psychotherapy is still needed to support patients even after the clinical depression is remitted.