Objective: To determine the relationship between burnout and personality among residents. Method: Cross-sectional study using an anonymous handled survey on Suez Canal University Hospital residents. Maslach Burnout Inventory and The 100 Big-Five Factor Markers Questionnaire (long form) of the International Personality Item Pool (IPIP) were used to measure Burnout and Personality, respectively. Results: Among 84 (64.6%) responding residents, significant relationship was found between burnout domains and the five personality dimensions. Both emotional exhaustion and depersonalization had significant negative correlation with each of the five personality dimensions. Personal accomplishment had a significant positive correlation with each of the personality dimensions. Conclusion: Burnout is a problem closely related to and highly influenced by the personality characteristics of physicians.