This paper aimed at developing and validating a Lebanese adapted scale for psychological distress screening, since psychological health is becoming increasingly important and culturally validated assessing tools are essential in a developing country. The study was performed on three samples. Based on 22 items, a score was established and subsequently subjected to an exploratory factor analysis, leading to the determination of six factors, its structure was confirmed in a confirmatory factor analysis. Reliability and test-retest reproducibility were then measured, added to convergent and discriminant validities. Results were clinically validated on a sample of individuals with diagnosed clinical disease. The BDS-22 included six factors, reflecting: depressive symptoms, demotivation, psychosomatic symptoms, mood deterioration, intellectual inhibition and anxiety. Adequate internal consistency and test-retest reproducibility were stated, both factors and the total scale correlated adequately with SRQ-20, SF-36 (psychological component), GHQ-12, MHI-5 and WHO-5 scales. The BDS-22 was also able to distinguish between male and female psychological distress. Results were psychologically well-founded. However, this score would need a clinical cross-validation before turning into a useful tool for psychological distress evaluation, interpreted as precocious signs and symptoms of serious physical, psychological and social dysfunctions.