Abstract There are concerns about the safety of the dextropropoxyphene and acetaminophen fixed‐dose combination, particularly in patients with psychiatric morbidity, which has led to a phased withdrawal of this fixed‐dose combination in many countries. A retrospective prescription audit was conducted to evaluate the dextropropoxyphene + acetaminophen fixed‐dose combination prescribing pattern in the major psychiatric hospital of Bahrain. The data analysis was performed using SPSS/PC+ version 14.0. Prescriptions with the dextropropoxyphene + acetaminophen fixed‐dose combination comprised 11.8% of all dispensed prescriptions and in most instances for outpatients undergoing substance abuse rehabilitation. Nearly half of the patients received ≥20 tablets of this fixed‐dose combination (mean ± SD: 30.9 ± 13.1; range 20–126) as multiple doses. The dextropropoxyphene + acetaminophen fixed‐dose combination was often co‐prescribed with psychotropics, such as benzodiazepines (BZDs) (25.4%), BZDs + antidepressants (62.9%), BZDs + antipsychotics (3.7%) and BZDs + anticonvulsants (1.9%). Approximately 40% of prescriptions with the dextropropoxyphene + acetaminophen fixed‐dose combination were written ‘as required’ (prn ), basis. Despite poor safety and efforts to restrict or withdraw worldwide, the dextropropoxyphene + acetaminophen fixed‐dose combination continues to be irrationally prescribed to outpatients undergoing substance abuse rehabilitation in Bahrain. Health policy decision‐makers should introduce a phased withdrawal of this drug from clinical use. In the meanwhile, it is important to create awareness among prescribers of the risks associated with over‐dosage of the dextropropoxyphene + acetaminophen fixed‐dose combination and its interaction with other psychotropic medications.