Objectives: To determine the effect of physical and mental stressors on pressure pain thershold (PPT), and pressure pain tolerance (PTOL) values, and to compre these different types of stressors on its ability to affect PPT and PTOL values in young women. We also correlated body mass index (BMI) with PPT and PTOL in young women. Methods: This was self-controlled study carried out on 79 second-year female medical student in the Department of Physiology, King Faisal University, Dammam, Saudia Arabia during the year 2007. The students were assessed before, and sfter they were subjected to a mental (exam), and two physical stressors. Measurments of PPT and PTOL were carried out using a pressure algometer. The 2 physical stressors used were: cold water immesrsion and isometric exersice (ISO EX).with a dynamometer. Students' body mass index were measured in addition to the measurement of blood pressure and heart rate for each student before, and after exposure to the stressors. Results: All 3 stressors significantly incrased the PPT values (p=0.000). The PTOL was also significanlty increased immediatly after exposure to the physical stressors (p=0.000), while for the mental stressors, the PTOL readings were not significantly increased. Among the 3 types of the stressors, the cold water immersion was the most affective in increasing PPT and PTOL. Moreover, a significant (p=0.009) negative correlation and demonstrated between the BMI and PTOL readings. Conclusion: VArious types of physical and mental stressors significantly increased PPT and PTOL readings in young female adults, in addition to the significant findings that students with higher body mass index tolerated pain less.