Long-term effects of acute and of chronic hypoxia on behavior and on hippocampal histology in the developing brain.
Author: Mikati MA, Zeinieh MP, Kurdi RM, Harb SA, El Hokayem JA, Daderian RH, Shamseddine A, Obeid M, Bitar FF, El Sabban M.
Source:
Developmental brain research, 157(1), 98-102.
Ten-day-old rat pups (P10) subjected to acute hypoxia (down to 4% O2) had as
adults increased aggression (handling test), memory impairment (water maze test),
and decreased CA1 cell counts. Pups subjected to chronic hypoxia (10% O2 from P0
to P21) had increased aggression, hyperactivity (open-field test), and decreased
CA1 cell counts. Chronic hypoxia with superimposed acute hypoxia resulted in
consequences that were not different from those of chronic hypoxia.