The premenstrual syndrome and premenstrual dysphoric disorder, both cyclical disorders of reproductive women and interfacing between gynecology and psychiatry in multiple domains are specifically linked to the late luteal phase of menstrual cycle. This paper analyses anamneses of five patients who manifested physical and psychological symptoms symbolic of a spectrum of premenstrual disorders and also endorsed therapeutic value of serotonin re-uptake inhibitors. In consideration of these cases, the relevant revealed findings are discussed in the light of international data.