This chapter examines the theoretical constructs of the relational-cultural model of therapy, stating that it represents a departure from the separate-self view of development and posits that we grow in, through, and toward relationship. Therapy from this perspective involves an attitudinal more than a technical change on the part of the therapist who profoundly respects the potential movement of a patient into growth-fostering relationships. Therapy based on a relational-cultural model addresses issues of isolation, connection, and disconnection. This type of therapy is not based on a sophisticated set of techniques, but depends largely on an attitude of mutual respect and inquiry. Much of the work involves around making meaning, understanding the relational expectations and relational images a patient brings to new relationships, and looking at the patterns of disconnections. The therapy relationship itself embodies healing. Mutual empathy provides a key to change and growth. Cases examples are provided.