The relationship between various physical indoor environmental factors and the level of the studied depression aspects had been investigated. The study has been tried to involve patients suffering from different levels of depression and treated at specialized mental hospitals. Significant negative correlation had established been the between efficient indoor physical environment such as available basic home facilities, ventilation and sunny environment, home satisfaction, neighborhood physical environment and work physical environment, and the increased levels of depression aspects namely, physiological, attitude, behavior, social, situational, self satisfaction and self insight of depression. Recommendations were advised to add improvement of indoor physical environment to the line of depression treatment and to evaluate the efficiency of improving the work physical environment and its outcome in improving the physical and mental health of the workers with expected increased productivity and efficiency of the exposed workers.