Discusses Problem-Solving Treatment for Primary Care (PST-PC), developed as a practical and brief intervention for treatment of depressive disorders in the primary care setting. The authors describe the treatment rationale, procedures, and empirical evidence for its effectiveness. PST-PC was studied in the Treatment Effectiveness Project (TEP), which involved 2 parallel trials comparing PST-PC, a serotonin reuptake inhibitor antidepressant and placebo. One study involved patients aged 18-59 yrs, and the other patients aged 60 yrs and older. The training program for TEP therapists to administer PST-PC is also described, which involved psychologists, social workers and counselors. Results of the TEP suggest that patients readily adhered to PST-PC treatment. Other lessons learned from the TEP, recommendations for practice and future research are included.