Conceptually, the Lithium Clinic provides an ideal and cost-effective setting for the long-term management of affective disorders. There has been a drive for Lithium-treated patients to be managed in hospital-based psychiatric clinics and rarely in primary care as part of the move from specialism to generalism in health care. The advantages of the lithium clinic in ensuring better care, compliance, monitoring, and support need to be safeguarded in general psychiatric and primary care clinics by adherence to clinical practice guidelines.