The purpose of this study was to explore the influence of the interaction between sex of patient and sex of nurse on the comfort of nurses while providing the bio-psychosocial and educational care in its two forms: private, and general care. The study employed a randomized factorial design PQ and utilized a stratified random sample of 185 males and 220 females. The data was collected by means of a questionnaire that was developed by the researcher. The validity and the reliability were maintained. Two-way ANOVA (sex of nurse times sex of patient), and t-test were utilized to provide answers for the research questions. The results showed that nurses comfort in providing the general form of bio-psychosocial and educational care increased significantly when they deal with patients from the same sex as them, and decreased significantly in providing the private form of biopsychosocial and educational care for patients from the opposite sex.