Cortisol and prolactin levels were estimated after both a dexamethasone suppression test (DST) and cortisol suppression test (CST) had been done in series in 26 depressive patients and 29 normal controls. Results of the DST were generally consistent with those obtained with other investigations showing greater nonsuppression of cortisol in depressive patients than in normal Ss. Cortisol responses, however, were not suppressed after CST, and similar values were obtained in depressive patients and normal Ss. The prolactin response to CST was significantly greater in depressive patients than in normal Ss. Changes in CST and DST cortisol and prolactin values were not related to changes in affective morbidity over 3 wks of treatment.