A previously healthy and immuno-competent 22-year-old man presented in confusional psychosis. Cryptococcal meningitis was later found to be the underlying cause as proven by culturing Cryptococcus neoformans serotype A from the cerebrospinal fluid. Combined antifungal therapy with amphotericin B and 5-fluorocytosine resulted in sustained improvement of all mental and physical functions. Cryptococcosis has rarely been reported from the Middle East. This represents the second case from Kuwait.