We compared the determinants and consequences of burnout for Canadian (N = 586) and Jordanian (N = 263) registered nurses working in a hospital setting. LISREL 7 software was used to perform a path analysis testing hypothesized relationships between job satisfaction dimensions (supervision, hospital identification, kind of work, amount of work, physical work conditions, rewards, and career future) and burnout and intention to quit. For both Canadian and Jordanian nurses, kind of work, amount of work, and career future were important determinants of burnout. Career future and burnout (emotional exhaustion) were associated with intention to quit on the basis of the highly similar results across the two samples, we propose that a universal theoretical model of the determinants and consequences of burnout among nurses may be plausible.