Rapid-cycling Bipolar Disorder: Cross-national Community Study.

Year: 2010
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Lee S, Tsang A, Kessler RC, Jin R, Sampson N, Andrade L, Karam E, Medina Mora ME, Merikangas K, Nakane Y, Popovici DG, PoSada-Vlla J, Sagar R, Wells JE, Zarkov Z


The epidemiology of rapid-cycling bipolar disorder in the community is largely unknown.
To investigate the epidemiological characteristics of rapid-cycling and non-rapid-cycling bipolar disorder in a large cross-national community sample.
The Composite International Diagnostic Interview (CIDI version 3.0) was used to examine the prevalence, severity, comorbidity, impairment, suicidality, sociodemographics, childhood adversity and treatment of rapid-cycling and non-rapid-cycling bipolar disorder in ten countries (n = 54 257).
The 12-month prevalence of rapid-cycling bipolar disorder was 0.3%. Roughly a third and two-fifths of participants with lifetime and 12-month bipolar disorder respectively met criteria for rapid cycling. Compared with the non-rapid-cycling, rapid-cycling bipolar disorder was associated with younger age at onset, higher persistence, more severe depressive symptoms, greater impairment from depressive symptoms, more out-of-role days from mania/hypomania, more anxiety disorders and an increased likelihood of using health services. Associations regarding childhood, family and other sociodemographic correlates were less clear cut.
The community epidemiological profile of rapid-cycling bipolar disorder confirms most but not all current clinically based knowledge about the illness. British Journal of Psychiatry, 196(3), 217-225.


Bipolar Disorder,L.E.B.A.N.O.N Study,Mental Health Around the World


Rapid Cycling,Bipolar Disorder,Bipolarity,Cross-national
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